Лаборатория доклинических исследований
Молекулярные механизмы иммунного ответа
Команда лаборатории
Алашеев Антон
Заведующий лабораторией
Долотова Ольга
Старший научный сотрудник
Кандидат химических наук
Кандидат химических наук
Земцов Артем
Старший научный сотрудник
Кандидат химических наук
Кандидат химических наук
Константинов Игорь
Старший научный сотрудник
Кандидат химических наук
Кандидат химических наук
Бабак Николай
Научный сотрудник
Кандидат химических наук
Кандидат химических наук
Фильков Глеб
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Мелерзанов Александр
Старший научный сотрудник
Кандидат медицинских наук
Кандидат медицинских наук
Дигтярь Антон
Научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Корзинов Олег
Научный сотрудник
Саранцева Ирина
Младший научный сотрудник
Цыриков Павел
Младший научный сотрудник
Шапошникова Наталья
Младший научный сотрудник
Амочкин Кирилл
Инженер
Афанасьев Юрий
Инженер
Барит Нургиса
Инженер
Ван Юйчжэ
Инженер
Кирдяшкин Сергей
Инженер
Куканова Юлия
Инженер
Сергеев Владимир
Инженер
Сюе Вэньюй
Инженер
Шкиль Дмитрий
Исследователь
Бутузова Наталья
Ведущий специалист
Вячеславов Алексей
Специалист
Козлова Светлана
Специалист
Наварро Марина
Специалист
Сашова Наталья
Эксперт
Чернов Даниил
Техник
Быданов Давид
Лаборант
Должанский Роман
Лаборант
Киселев Глеб
Лаборант
Клячина Алена
Лаборант
Кокорева Вера
Лаборант
Курохтин Александр
Лаборант
Кухани Арина
Лаборант
Лавренова Анастасия
Лаборант
Латыпова Шаура
Лаборант
Никифорова Лариса
Лаборант
Нузбаев Карим
Лаборант
Оськина Мария
Лаборант
Рязанцева Татьяна
Лаборант
Хасьянова Елена
Лаборант
Хорошкова Ольга
Лаборант
Щербинина Екатерина
Лаборант
Направления деятельности
1
Комплексные междисциплинарные исследования
Исследования на стыке молекулярной и клеточной биологии, генной инженерии, физики, химии, биотехнологии и нанотехнологий
2
Работа с живыми объектами
Исследования с использованием бактерий, эукариотических клеток, органоидов, лабораторных грызунов
3
Развитие научной коммуникации
Сотрудничество с академическими институтами — ИОФ РАН, ИБХ РАН; образовательными учреждениями — НИЯУ МИФИ, научно-технологическим университетом «Сириус»; с ООО АБИСЕНС — российским производителем научного оборудования
4
Педагогика и популяризация науки
Образовательная деятельность в ведущих вузах, в т. ч. МФТИ, РГАУ-МСХА, Университет Сириус; активное освещение результатов научной деятельности
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Аналитика и контроль качества
- Физико-химическая аналитика
- Разработка и валидация методик анализа
- Контроль качества и анализ состава продукции
- Определение загрязняющих веществ и контаминантов
- Экологический мониторинг
- Разработка и валидация физико-химических методов анализа:
- ВЭЖХ-МС/МС, ВЭЖХ-УФ, ГХ-МС
- Разработка и валидация спектрофотометрических методик: ВЭЖХ-МС/МС, ИФА
Технологии и производство
- Технологии производства лекарственных форм
- Разработка технологий синтеза и масштабирования
- Оптимизация производственных процессов
- Поддержка GMP и стандартизация
- Технико-экономический анализ и валидация
Документация и регистрация
- Подготовка регистрационного досье
- Сопровождение регистрации препаратов
- Работа с нормативной документацией
- Поддержка фармаконадзора
- Научно-методическое сопровождение заявок
Фармакология и лекарственные формы
- Фармакология
- Активные фармацевтические субстанции
- Готовые лекарственные формы
- Химический синтез
- Биосинтез
- Технологии производства готовых лекарственных форм
- Разработка технологий синтеза АФС
- Разработка технологий производства твёрдых лекарственных форм
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Основные публикации
Shramova, E. I., Chumakov, S. P., Shipunova, V. O., Ryabova, A. V., Telegin, G. B., Kabashin, A. V., … Proshkina, G. M. (2022). Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Light: Science & Applications, 11(1), 38. doi: 10.1038/s41377−022−729−4. IF 19.4 Q1.
Tselikov, G., Danilov, A., Shipunova, V., Deyev, S., Kabashin, A., Grigorenko, A. (2023). Topological Darkness: How to Design a Metamaterial for Optical Biosensing with Ultrahigh Sensitivity. ACS Nano, accepted. doi: 10.1021/acsnano.3c06655. IF 17.1. Q1.
Zelepukin, I. V., Mashkovich, E. A., Lipey, N. A., Popov, A. A., Shipunova, V. O., Griaznova, O. Y., … Zvyagin, A. V. (2022). Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating. Chemical Engineering Journal, 430, 132 860. doi: 10.1016/j.cej.2021.132 860. IF 15.1. Q1.
Ukrainskaya, V., Rubtsov, Y., Pershin, D., Podoplelova, N., Terekhov, S., Yaroshevich, I., … Shipunova, V., … Lerner, R. (2021). Antigen-Specific Stimulation and Expansion of CAR-T Cells Using Membrane Vesicles as Target Cell Surrogates. Small, 17(45), 2 102 643. doi: 10.1002/smll.202 102 643. IF 13.3. Q1.
Stepanov, A. V.*, Kalinin, R. S.*, Shipunova, V. O.*, Zhang, D., Xie, J., Rubtsov, Y. P., … & Altman, S. (2022). Switchable targeting of solid tumors by BsCAR T cells. Proceedings of the National Academy of Sciences, 119(46), e2210562119. doi: 10.1073/pnas.2 210 562 119. IF 11.1. Q1. *equal contribution
Komedchikova, E.N.; Kolesnikova, O.A.; Syuy, A.V.; Volkov V.S.; Deyev, S.M.; Nikitin, M.P.; Shipunova, V.O. (2023). Targosomes: Anti-HER2 PLGA Nanocarriers for Bioimaging, Chemotherapy and Local Photothermal Treatment of Tumors and Remote Metastases. Journal of Controlled Release. doi: 10.1016/j.jconrel.2023.11.036. IF 10.8. Q1.
Petrunina, N. A., Shtork, A. S., Lukina, M. M., Tsvetkov, V. B., Khodarovich, Y. M., Feofanov, A. V., … Shipunova, V. O., … Varizhuk, A. M. (2023). Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in the Nucleoplasm and Interchromatin Granules. ACS Sensors, 8(2), 619−629. doi: 10.1021/acssensors.2c01813. IF 8.9. Q1.
Zelepukin, I. V., Popov, A. A., Shipunova, V. O., Tikhonowski, G. V., Mirkasymov, A. B., Popova-Kuznetsova, E. A., … & Deyev, S. M. (2021). Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science and Engineering: C (=Biomaterials Advances), 120, 111 717. doi: 10.1016/j.msec.2020.111 717. IF 7.9. Q1.
Nikitin M.P., Shipunova V.O., Deyev S.M. and Nikitin P.I. Biocomputing based on particle disassembly. Nature Nanotechnology 9 (9), 716 (2014). IF 38.3. Q1.
Nikitin M.P.*, Zelepukin I.V.*, Shipunova V.O., Sokolov I.L., Deyev S.M., Nikitin P.I. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes. Nature Biomedical Engineering 4(7), 717−731 (2020). IF 29.2. Q1.
Mitiouchkina T., Mishin A.S., Gonzalez Somermeyer L., Markina N.M., Chepurnyh T.V., Guglya E.B., Karataeva T.A., Palkina K.A., Shakhova E.S., Fakhranurova L.I., Chekova S.V., Tsarkova A.S., Golubev Y.V., Negrebetsky V.V., Dolgushin S.A., Shalaev P.V., Shlykov D., Melnik O.A., Shipunova V.O., Deyev S.M., Bubyrev A.I., Pushin A.S., Choob V.V., Dolgov S.V., Kondrashov F.A., Yampolsky I.V. & Sarkisyan K.S. Plants with genetically encoded autoluminescence. Nature Biotechnology 1−3 (2020). IF 54.908. IF 29.2. Q1.
Kabashin A.V., Kravets V.G., Wu F., Imaizumi S., Shipunova V.O., Deyev S.M., Grigorenko A.N. Phase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces. Advanced Functional Materials 29 1 902 692 (2019). IF 19. Q1.
Shipunova V.O., Komedchikova E.N., Kotelnikova P.A., Zelepukin I.V., Schulga A.A., Proshkina G.M., Shramova E.I., Kutscher H.L., Telegin G.B., Kabashin A.V., Prasad P.N., Deyev S.M. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano (2020). IF 17.1. Q1.
Shipunova V.O., Zelepukin I.V., Stremovskiy O.A., Nikitin M.P., Care A., Sunna A., Zvyagin A.V., Deyev S.M. Versatile Platform for Nanoparticle Surface Bioengineering Based on SiO2‑Binding Peptide and Proteinaceous Barnase*Barstar Interface. ACS Applied Materials & Interfaces 10 (20), 17 437−17 447 (2018). IF 9.229.
Shipunova V.O., Nikitin M.P., Nikitin P.I., Deyev S.M. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interactions. Nanoscale 8 (25), 12 764−12 772 (2016). IF 6.7. Q1.
Tselikov, G., Danilov, A., Shipunova, V., Deyev, S., Kabashin, A., Grigorenko, A. (2023). Topological Darkness: How to Design a Metamaterial for Optical Biosensing with Ultrahigh Sensitivity. ACS Nano, accepted. doi: 10.1021/acsnano.3c06655. IF 17.1. Q1.
Zelepukin, I. V., Mashkovich, E. A., Lipey, N. A., Popov, A. A., Shipunova, V. O., Griaznova, O. Y., … Zvyagin, A. V. (2022). Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating. Chemical Engineering Journal, 430, 132 860. doi: 10.1016/j.cej.2021.132 860. IF 15.1. Q1.
Ukrainskaya, V., Rubtsov, Y., Pershin, D., Podoplelova, N., Terekhov, S., Yaroshevich, I., … Shipunova, V., … Lerner, R. (2021). Antigen-Specific Stimulation and Expansion of CAR-T Cells Using Membrane Vesicles as Target Cell Surrogates. Small, 17(45), 2 102 643. doi: 10.1002/smll.202 102 643. IF 13.3. Q1.
Stepanov, A. V.*, Kalinin, R. S.*, Shipunova, V. O.*, Zhang, D., Xie, J., Rubtsov, Y. P., … & Altman, S. (2022). Switchable targeting of solid tumors by BsCAR T cells. Proceedings of the National Academy of Sciences, 119(46), e2210562119. doi: 10.1073/pnas.2 210 562 119. IF 11.1. Q1. *equal contribution
Komedchikova, E.N.; Kolesnikova, O.A.; Syuy, A.V.; Volkov V.S.; Deyev, S.M.; Nikitin, M.P.; Shipunova, V.O. (2023). Targosomes: Anti-HER2 PLGA Nanocarriers for Bioimaging, Chemotherapy and Local Photothermal Treatment of Tumors and Remote Metastases. Journal of Controlled Release. doi: 10.1016/j.jconrel.2023.11.036. IF 10.8. Q1.
Petrunina, N. A., Shtork, A. S., Lukina, M. M., Tsvetkov, V. B., Khodarovich, Y. M., Feofanov, A. V., … Shipunova, V. O., … Varizhuk, A. M. (2023). Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in the Nucleoplasm and Interchromatin Granules. ACS Sensors, 8(2), 619−629. doi: 10.1021/acssensors.2c01813. IF 8.9. Q1.
Zelepukin, I. V., Popov, A. A., Shipunova, V. O., Tikhonowski, G. V., Mirkasymov, A. B., Popova-Kuznetsova, E. A., … & Deyev, S. M. (2021). Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science and Engineering: C (=Biomaterials Advances), 120, 111 717. doi: 10.1016/j.msec.2020.111 717. IF 7.9. Q1.
Nikitin M.P., Shipunova V.O., Deyev S.M. and Nikitin P.I. Biocomputing based on particle disassembly. Nature Nanotechnology 9 (9), 716 (2014). IF 38.3. Q1.
Nikitin M.P.*, Zelepukin I.V.*, Shipunova V.O., Sokolov I.L., Deyev S.M., Nikitin P.I. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes. Nature Biomedical Engineering 4(7), 717−731 (2020). IF 29.2. Q1.
Mitiouchkina T., Mishin A.S., Gonzalez Somermeyer L., Markina N.M., Chepurnyh T.V., Guglya E.B., Karataeva T.A., Palkina K.A., Shakhova E.S., Fakhranurova L.I., Chekova S.V., Tsarkova A.S., Golubev Y.V., Negrebetsky V.V., Dolgushin S.A., Shalaev P.V., Shlykov D., Melnik O.A., Shipunova V.O., Deyev S.M., Bubyrev A.I., Pushin A.S., Choob V.V., Dolgov S.V., Kondrashov F.A., Yampolsky I.V. & Sarkisyan K.S. Plants with genetically encoded autoluminescence. Nature Biotechnology 1−3 (2020). IF 54.908. IF 29.2. Q1.
Kabashin A.V., Kravets V.G., Wu F., Imaizumi S., Shipunova V.O., Deyev S.M., Grigorenko A.N. Phase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces. Advanced Functional Materials 29 1 902 692 (2019). IF 19. Q1.
Shipunova V.O., Komedchikova E.N., Kotelnikova P.A., Zelepukin I.V., Schulga A.A., Proshkina G.M., Shramova E.I., Kutscher H.L., Telegin G.B., Kabashin A.V., Prasad P.N., Deyev S.M. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano (2020). IF 17.1. Q1.
Shipunova V.O., Zelepukin I.V., Stremovskiy O.A., Nikitin M.P., Care A., Sunna A., Zvyagin A.V., Deyev S.M. Versatile Platform for Nanoparticle Surface Bioengineering Based on SiO2‑Binding Peptide and Proteinaceous Barnase*Barstar Interface. ACS Applied Materials & Interfaces 10 (20), 17 437−17 447 (2018). IF 9.229.
Shipunova V.O., Nikitin M.P., Nikitin P.I., Deyev S.M. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interactions. Nanoscale 8 (25), 12 764−12 772 (2016). IF 6.7. Q1.
Основные публикации
V. O. Shipunova, E. N. Komedchikova, P. A. Kotelnikova, I. V. Zelepukin, A. A. Schulga, G. M. Proshkina, E. I. Shramova, H. L. Kutscher, G. B. Telegin, A. V. Kabashin, P. N. Prasad, and S. M. Deyev. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano Article ASAP (Q1) — 2020. DOI: 10.1021/acsnano.0c03421.
Shipunova VO, Belova MM, Kotelnikova PA, Shilova ON, Mirkasymov AB, Danilova NV, Komedchikova EN, Popovtzer R, Deyev SM, Nikitin MP. Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission. Pharmaceutics (Q1). 2022; 14(5):1013. doi.org/10.3390/pharmaceutics14051013.
Obozina, A. S., Komedchikova, E. N., Kolesnikova, O. A., Iureva, A. M., Kovalenko, V. L., Zavalko, F. A., Rozhnikova, T.V., Tereshina, E. D., Mochalova E. N., Shipunova, V. O. (2023). Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics (Q1), 15(1), 231. DOI: 10.3390/pharmaceutics15010231.
Kovalenko, V. L., Komedchikova, E. N., Sogomonyan, A. S., Tereshina, E. D., Kolesnikova, O. A., Mirkasymov, A. B., Iureva, A. M., Zvyagin A.V., Nikitin P.I., Shipunova, V. O. (2023). Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics (Q1), 15(1), 92. DOI: 10.3390/pharmaceutics15010092.
Komedchikova, E. N., Kolesnikova, O. A., Tereshina, E. D., Kotelnikova, P. A., Sogomonyan, A. S., Stepanov, A. V., Deyev S.M., Nikitin M.P., Shipunova, V. O. (2023). Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics (Q1), 15(1), 52. DOI: 10.3390/pharmaceutics15010052.
Drozdov, A. S., Komarova, K. S., Mochalova, E. N., Komedchikova, E. N., Shipunova, V. O., & Nikitin, M. P. (2023). Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification. International Journal of Molecular Sciences (Q1), 24(1), 134. DOI: 10.3390/ijms24010134.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Shipunova VO, Belova MM, Kotelnikova PA, Shilova ON, Mirkasymov AB, Danilova NV, Komedchikova EN, Popovtzer R, Deyev SM, Nikitin MP. Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission. Pharmaceutics (Q1). 2022; 14(5):1013. doi.org/10.3390/pharmaceutics14051013.
Obozina, A. S., Komedchikova, E. N., Kolesnikova, O. A., Iureva, A. M., Kovalenko, V. L., Zavalko, F. A., Rozhnikova, T.V., Tereshina, E. D., Mochalova E. N., Shipunova, V. O. (2023). Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics (Q1), 15(1), 231. DOI: 10.3390/pharmaceutics15010231.
Kovalenko, V. L., Komedchikova, E. N., Sogomonyan, A. S., Tereshina, E. D., Kolesnikova, O. A., Mirkasymov, A. B., Iureva, A. M., Zvyagin A.V., Nikitin P.I., Shipunova, V. O. (2023). Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics (Q1), 15(1), 92. DOI: 10.3390/pharmaceutics15010092.
Komedchikova, E. N., Kolesnikova, O. A., Tereshina, E. D., Kotelnikova, P. A., Sogomonyan, A. S., Stepanov, A. V., Deyev S.M., Nikitin M.P., Shipunova, V. O. (2023). Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics (Q1), 15(1), 52. DOI: 10.3390/pharmaceutics15010052.
Drozdov, A. S., Komarova, K. S., Mochalova, E. N., Komedchikova, E. N., Shipunova, V. O., & Nikitin, M. P. (2023). Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification. International Journal of Molecular Sciences (Q1), 24(1), 134. DOI: 10.3390/ijms24010134.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Основные публикации
Shipunova VO, Kolesnikova OA, Kotelnikova PA, Soloviev VD, Popov AA, Proshkina GM, Nikitin MP, Deyev SM. Comparative Evaluation of Engineered Polypeptide Scaffolds in HER2-Targeting Magnetic Nanocarrier Delivery. ACS Omega. 2021 Jun 10;6(24):16 000−16 008. doi: 10.1021/acsomega.1c01811. IF 4.1, Q1.
Kovalenko VL, Kolesnikova OA, Nikitin MP, Shipunova VO, Komedchikova EN. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Basel). 2023 Aug 21;14(8):1647. doi: 10.3390/mi14081647. IF 3.4, Q2.
Obozina AS, Komedchikova EN, Kolesnikova OA, Iureva AM, Kovalenko VL, Zavalko FA, Rozhnikova TV, Tereshina ED, Mochalova EN, Shipunova VO. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics. 2023 Jan 10;15(1):231. doi: 10.3390/pharmaceutics15010231. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Tereshina ED, Kotelnikova PA, Sogomonyan AS, Stepanov AV, Deyev SM, Nikitin MP, Shipunova VO. Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics. 2022 Dec 24;15(1):52. doi: 10.3390/pharmaceutics15010052. IF 5.4, Q1.
Kovalenko VL, Komedchikova EN, Sogomonyan AS, Tereshina ED, Kolesnikova OA, Mirkasymov AB, Iureva AM, Zvyagin AV, Nikitin PI, Shipunova VO. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics. 2022 Dec 27;15(1):92. doi: 10.3390/pharmaceutics15010092. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release. 2024 Jan;365:317−330. doi: 10.1016/j.jconrel.2023.11.036. Epub 2023 Nov 25. PMID: 37 996 056. IF 10.8, Q1.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Kovalenko VL, Kolesnikova OA, Nikitin MP, Shipunova VO, Komedchikova EN. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Basel). 2023 Aug 21;14(8):1647. doi: 10.3390/mi14081647. IF 3.4, Q2.
Obozina AS, Komedchikova EN, Kolesnikova OA, Iureva AM, Kovalenko VL, Zavalko FA, Rozhnikova TV, Tereshina ED, Mochalova EN, Shipunova VO. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics. 2023 Jan 10;15(1):231. doi: 10.3390/pharmaceutics15010231. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Tereshina ED, Kotelnikova PA, Sogomonyan AS, Stepanov AV, Deyev SM, Nikitin MP, Shipunova VO. Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics. 2022 Dec 24;15(1):52. doi: 10.3390/pharmaceutics15010052. IF 5.4, Q1.
Kovalenko VL, Komedchikova EN, Sogomonyan AS, Tereshina ED, Kolesnikova OA, Mirkasymov AB, Iureva AM, Zvyagin AV, Nikitin PI, Shipunova VO. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics. 2022 Dec 27;15(1):92. doi: 10.3390/pharmaceutics15010092. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release. 2024 Jan;365:317−330. doi: 10.1016/j.jconrel.2023.11.036. Epub 2023 Nov 25. PMID: 37 996 056. IF 10.8, Q1.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Основные публикации
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. doi.org/10.3390/pharmaceutics15010231.
Основные публикации
Iureva et al. The influence of various polymer coatings on the in vitro and in vivo properties of PLGA nanoparticles: Comprehensive study // European Journal of Pharmaceutics and Biopharmaceutics. — 2024. — С. 114 366.
Kovalenko V. L. et al. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo //Pharmaceutics. — 2022. — Т. 15. — №. 1. — С. 92.
Obozina A. S. et al. Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo //Pharmaceutics. — 2023. — Т. 15. — №. 1. — С. 231.
Kotelnikova P. A. et al. Peroxidase-like activity of silver nanowires and its application for colorimetric detection of the antibiotic chloramphenicol //Talanta Open. — 2022. — Т. 6. — С. 100 164.
Kovalenko V. L. et al. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo //Pharmaceutics. — 2022. — Т. 15. — №. 1. — С. 92.
Obozina A. S. et al. Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo //Pharmaceutics. — 2023. — Т. 15. — №. 1. — С. 231.
Kotelnikova P. A. et al. Peroxidase-like activity of silver nanowires and its application for colorimetric detection of the antibiotic chloramphenicol //Talanta Open. — 2022. — Т. 6. — С. 100 164.
Основные публикации
Optical clearing of tissues: issues of antimicrobial phototherapy and drug delivery. VV Tuchin, EA Genina, ES Tuchina, AV Svetlakova, YI Svenskaya, Advanced Drug Delivery Reviews.
Исследование фотокаталитической антимикробной активности нанокомпозитов на основе TiO–AlO при воздействии светодиодного излучения. АВ Светлакова, ЕС Тучина, АН Ходан, ВВ Тучин, Оптика и спектроскопия.
Новые гипс-титановые композиты для антимикробного фотокаталитического воздействия на Staphylococcus aureus, Е Тучина, МВ Корченова, АВ Светлакова, К Криштиану, ВВ Тучин, Известия Саратовского университета. Новая серия.
Исследование фотокаталитической антимикробной активности нанокомпозитов на основе TiO–AlO при воздействии светодиодного излучения. АВ Светлакова, ЕС Тучина, АН Ходан, ВВ Тучин, Оптика и спектроскопия.
Новые гипс-титановые композиты для антимикробного фотокаталитического воздействия на Staphylococcus aureus, Е Тучина, МВ Корченова, АВ Светлакова, К Криштиану, ВВ Тучин, Известия Саратовского университета. Новая серия.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
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