Лаборатория персонализированной химио-лучевой терапии
Системы оценки метастатического и рецидивного потенциала опухолей
Команда лаборатории
Пустовалова Маргарита Витальевна
Заведующая лабораторией
Кандидат биологических наук
Кандидат биологических наук
Кузьмин Денис Владимирович
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Леонов Сергей Викторович
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Марусич Елена Ивановна
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Чупров-Неточин Роман Николаевич
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Чигасова Анна Константиновна
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Розенберг Юлий Маркович
Старший научный сотрудник
Кандидат биологических наук
Кандидат биологических наук
Контарева Елизавета Гумаровна
Младший научный сотрудник
Зрилова Юлия Андреевна
Инженер
Максимова Ксения Владимировна
Инженер
Нофал Зейн
Научный сотрудник
Александрова Анастасия Викторовна
Лаборант
Смирнова Анна Владимировна
Лаборант
Салимон Саобан Сунканми
Лаборант
Некрасов Виктор Дмитриевич
Лаборант
Направления деятельности
1
Банк данных резистентных опухолей
Создание транскриптомного банка и библиотек клеточных линий с уникальными генетическими мутациями опухолей, устойчивых к химио- и лучевой терапии
2
Моделирование трансформации и устойчивости клеток
Оценка способности нормальных клеток превращаться в полиплоидные опухолевые формы с признаками радиорезистентности и потенциалом к репопуляции
3
Наносенсоры и инвазивные раковые клетки
Сравнительный анализ захвата и инкапсуляции наносенсоров различными субпопуляциями метастатических опухолевых клеток
4
Оптимизация облучения тяжёлыми частицами
Разработка схем облучения для наиболее устойчивых опухолей с использованием тяжёлых заряженных частиц
5
ИИ в прогнозировании метастазов
Разработка алгоритма на основе искусственного интеллекта для оценки персонализированного риска метастазирования у пациента
Научные интересы и Области работы
Модели, банки и клеточные линии
- Создание банка транскриптомных данных резистентных опухолей
- Библиотеки клеточных линий с уникальными мутациями
- Исследование нетрансформированных и трансформированных клеток
- Молекулярно-генетический анализ
- Клеточные линии и опухолевые стволовые клетки
Воздействие ионизирующего излучения
- Изучение эффектов радиации на мезенхимальные клетки
- Двуцепочечные разрывы ДНК после излучения
- Оптимизация облучения тяжёлыми заряженными частицами
- Ионизирующее излучение и его последствия
- Метастазирование после облучения
Искусственный интеллект и нанотехнологии
- Прогнозирование риска метастазов с помощью ИИ
- Использование AI для персонализированной терапии
- Захват и инкапсуляция частиц нано-сенсоров
- Эндоцитарные пути субпопуляций опухолевых клеток
- Нанотехнологии в таргетной доставке и анализе опухолей
Молекулярные маркеры и резистентность опухолей
- Идентификация онкоген-подобных драйверов хемо-/радиорезистентности
- Биомаркеры устойчивости опухолей НМРЛ и РМЖ
- Определение молекулярно-генетических параметров
- Оценка рисков для пациента перед терапией
- Радиорезистентность опухолевых стволовых клеток
- Полиплоидные опухолевые клетки и репопуляция
Новости ЛАБОРАТОРИИ
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Основные публикации
Shramova, E. I., Chumakov, S. P., Shipunova, V. O., Ryabova, A. V., Telegin, G. B., Kabashin, A. V., … Proshkina, G. M. (2022). Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors. Light: Science & Applications, 11(1), 38. doi: 10.1038/s41377−022−729−4. IF 19.4 Q1.
Tselikov, G., Danilov, A., Shipunova, V., Deyev, S., Kabashin, A., Grigorenko, A. (2023). Topological Darkness: How to Design a Metamaterial for Optical Biosensing with Ultrahigh Sensitivity. ACS Nano, accepted. doi: 10.1021/acsnano.3c06655. IF 17.1. Q1.
Zelepukin, I. V., Mashkovich, E. A., Lipey, N. A., Popov, A. A., Shipunova, V. O., Griaznova, O. Y., … Zvyagin, A. V. (2022). Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating. Chemical Engineering Journal, 430, 132 860. doi: 10.1016/j.cej.2021.132 860. IF 15.1. Q1.
Ukrainskaya, V., Rubtsov, Y., Pershin, D., Podoplelova, N., Terekhov, S., Yaroshevich, I., … Shipunova, V., … Lerner, R. (2021). Antigen-Specific Stimulation and Expansion of CAR-T Cells Using Membrane Vesicles as Target Cell Surrogates. Small, 17(45), 2 102 643. doi: 10.1002/smll.202 102 643. IF 13.3. Q1.
Stepanov, A. V.*, Kalinin, R. S.*, Shipunova, V. O.*, Zhang, D., Xie, J., Rubtsov, Y. P., … & Altman, S. (2022). Switchable targeting of solid tumors by BsCAR T cells. Proceedings of the National Academy of Sciences, 119(46), e2210562119. doi: 10.1073/pnas.2 210 562 119. IF 11.1. Q1. *equal contribution
Komedchikova, E.N.; Kolesnikova, O.A.; Syuy, A.V.; Volkov V.S.; Deyev, S.M.; Nikitin, M.P.; Shipunova, V.O. (2023). Targosomes: Anti-HER2 PLGA Nanocarriers for Bioimaging, Chemotherapy and Local Photothermal Treatment of Tumors and Remote Metastases. Journal of Controlled Release. doi: 10.1016/j.jconrel.2023.11.036. IF 10.8. Q1.
Petrunina, N. A., Shtork, A. S., Lukina, M. M., Tsvetkov, V. B., Khodarovich, Y. M., Feofanov, A. V., … Shipunova, V. O., … Varizhuk, A. M. (2023). Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in the Nucleoplasm and Interchromatin Granules. ACS Sensors, 8(2), 619−629. doi: 10.1021/acssensors.2c01813. IF 8.9. Q1.
Zelepukin, I. V., Popov, A. A., Shipunova, V. O., Tikhonowski, G. V., Mirkasymov, A. B., Popova-Kuznetsova, E. A., … & Deyev, S. M. (2021). Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science and Engineering: C (=Biomaterials Advances), 120, 111 717. doi: 10.1016/j.msec.2020.111 717. IF 7.9. Q1.
Nikitin M.P., Shipunova V.O., Deyev S.M. and Nikitin P.I. Biocomputing based on particle disassembly. Nature Nanotechnology 9 (9), 716 (2014). IF 38.3. Q1.
Nikitin M.P.*, Zelepukin I.V.*, Shipunova V.O., Sokolov I.L., Deyev S.M., Nikitin P.I. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes. Nature Biomedical Engineering 4(7), 717−731 (2020). IF 29.2. Q1.
Mitiouchkina T., Mishin A.S., Gonzalez Somermeyer L., Markina N.M., Chepurnyh T.V., Guglya E.B., Karataeva T.A., Palkina K.A., Shakhova E.S., Fakhranurova L.I., Chekova S.V., Tsarkova A.S., Golubev Y.V., Negrebetsky V.V., Dolgushin S.A., Shalaev P.V., Shlykov D., Melnik O.A., Shipunova V.O., Deyev S.M., Bubyrev A.I., Pushin A.S., Choob V.V., Dolgov S.V., Kondrashov F.A., Yampolsky I.V. & Sarkisyan K.S. Plants with genetically encoded autoluminescence. Nature Biotechnology 1−3 (2020). IF 54.908. IF 29.2. Q1.
Kabashin A.V., Kravets V.G., Wu F., Imaizumi S., Shipunova V.O., Deyev S.M., Grigorenko A.N. Phase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces. Advanced Functional Materials 29 1 902 692 (2019). IF 19. Q1.
Shipunova V.O., Komedchikova E.N., Kotelnikova P.A., Zelepukin I.V., Schulga A.A., Proshkina G.M., Shramova E.I., Kutscher H.L., Telegin G.B., Kabashin A.V., Prasad P.N., Deyev S.M. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano (2020). IF 17.1. Q1.
Shipunova V.O., Zelepukin I.V., Stremovskiy O.A., Nikitin M.P., Care A., Sunna A., Zvyagin A.V., Deyev S.M. Versatile Platform for Nanoparticle Surface Bioengineering Based on SiO2‑Binding Peptide and Proteinaceous Barnase*Barstar Interface. ACS Applied Materials & Interfaces 10 (20), 17 437−17 447 (2018). IF 9.229.
Shipunova V.O., Nikitin M.P., Nikitin P.I., Deyev S.M. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interactions. Nanoscale 8 (25), 12 764−12 772 (2016). IF 6.7. Q1.
Tselikov, G., Danilov, A., Shipunova, V., Deyev, S., Kabashin, A., Grigorenko, A. (2023). Topological Darkness: How to Design a Metamaterial for Optical Biosensing with Ultrahigh Sensitivity. ACS Nano, accepted. doi: 10.1021/acsnano.3c06655. IF 17.1. Q1.
Zelepukin, I. V., Mashkovich, E. A., Lipey, N. A., Popov, A. A., Shipunova, V. O., Griaznova, O. Y., … Zvyagin, A. V. (2022). Direct photoacoustic measurement of silicon nanoparticle degradation promoted by a polymer coating. Chemical Engineering Journal, 430, 132 860. doi: 10.1016/j.cej.2021.132 860. IF 15.1. Q1.
Ukrainskaya, V., Rubtsov, Y., Pershin, D., Podoplelova, N., Terekhov, S., Yaroshevich, I., … Shipunova, V., … Lerner, R. (2021). Antigen-Specific Stimulation and Expansion of CAR-T Cells Using Membrane Vesicles as Target Cell Surrogates. Small, 17(45), 2 102 643. doi: 10.1002/smll.202 102 643. IF 13.3. Q1.
Stepanov, A. V.*, Kalinin, R. S.*, Shipunova, V. O.*, Zhang, D., Xie, J., Rubtsov, Y. P., … & Altman, S. (2022). Switchable targeting of solid tumors by BsCAR T cells. Proceedings of the National Academy of Sciences, 119(46), e2210562119. doi: 10.1073/pnas.2 210 562 119. IF 11.1. Q1. *equal contribution
Komedchikova, E.N.; Kolesnikova, O.A.; Syuy, A.V.; Volkov V.S.; Deyev, S.M.; Nikitin, M.P.; Shipunova, V.O. (2023). Targosomes: Anti-HER2 PLGA Nanocarriers for Bioimaging, Chemotherapy and Local Photothermal Treatment of Tumors and Remote Metastases. Journal of Controlled Release. doi: 10.1016/j.jconrel.2023.11.036. IF 10.8. Q1.
Petrunina, N. A., Shtork, A. S., Lukina, M. M., Tsvetkov, V. B., Khodarovich, Y. M., Feofanov, A. V., … Shipunova, V. O., … Varizhuk, A. M. (2023). Ratiometric i-Motif-Based Sensor for Precise Long-Term Monitoring of pH Micro Alterations in the Nucleoplasm and Interchromatin Granules. ACS Sensors, 8(2), 619−629. doi: 10.1021/acssensors.2c01813. IF 8.9. Q1.
Zelepukin, I. V., Popov, A. A., Shipunova, V. O., Tikhonowski, G. V., Mirkasymov, A. B., Popova-Kuznetsova, E. A., … & Deyev, S. M. (2021). Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics. Materials Science and Engineering: C (=Biomaterials Advances), 120, 111 717. doi: 10.1016/j.msec.2020.111 717. IF 7.9. Q1.
Nikitin M.P., Shipunova V.O., Deyev S.M. and Nikitin P.I. Biocomputing based on particle disassembly. Nature Nanotechnology 9 (9), 716 (2014). IF 38.3. Q1.
Nikitin M.P.*, Zelepukin I.V.*, Shipunova V.O., Sokolov I.L., Deyev S.M., Nikitin P.I. Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes. Nature Biomedical Engineering 4(7), 717−731 (2020). IF 29.2. Q1.
Mitiouchkina T., Mishin A.S., Gonzalez Somermeyer L., Markina N.M., Chepurnyh T.V., Guglya E.B., Karataeva T.A., Palkina K.A., Shakhova E.S., Fakhranurova L.I., Chekova S.V., Tsarkova A.S., Golubev Y.V., Negrebetsky V.V., Dolgushin S.A., Shalaev P.V., Shlykov D., Melnik O.A., Shipunova V.O., Deyev S.M., Bubyrev A.I., Pushin A.S., Choob V.V., Dolgov S.V., Kondrashov F.A., Yampolsky I.V. & Sarkisyan K.S. Plants with genetically encoded autoluminescence. Nature Biotechnology 1−3 (2020). IF 54.908. IF 29.2. Q1.
Kabashin A.V., Kravets V.G., Wu F., Imaizumi S., Shipunova V.O., Deyev S.M., Grigorenko A.N. Phase-Responsive Fourier Nanotransducers for Probing 2D Materials and Functional Interfaces. Advanced Functional Materials 29 1 902 692 (2019). IF 19. Q1.
Shipunova V.O., Komedchikova E.N., Kotelnikova P.A., Zelepukin I.V., Schulga A.A., Proshkina G.M., Shramova E.I., Kutscher H.L., Telegin G.B., Kabashin A.V., Prasad P.N., Deyev S.M. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano (2020). IF 17.1. Q1.
Shipunova V.O., Zelepukin I.V., Stremovskiy O.A., Nikitin M.P., Care A., Sunna A., Zvyagin A.V., Deyev S.M. Versatile Platform for Nanoparticle Surface Bioengineering Based on SiO2‑Binding Peptide and Proteinaceous Barnase*Barstar Interface. ACS Applied Materials & Interfaces 10 (20), 17 437−17 447 (2018). IF 9.229.
Shipunova V.O., Nikitin M.P., Nikitin P.I., Deyev S.M. MPQ-cytometry: a magnetism-based method for quantification of nanoparticle-cell interactions. Nanoscale 8 (25), 12 764−12 772 (2016). IF 6.7. Q1.
Основные публикации
V. O. Shipunova, E. N. Komedchikova, P. A. Kotelnikova, I. V. Zelepukin, A. A. Schulga, G. M. Proshkina, E. I. Shramova, H. L. Kutscher, G. B. Telegin, A. V. Kabashin, P. N. Prasad, and S. M. Deyev. Dual Regioselective Targeting the Same Receptor in Nanoparticle-Mediated Combination Immuno/Chemotherapy for Enhanced Image-Guided Cancer Treatment. ACS Nano Article ASAP (Q1) — 2020. DOI: 10.1021/acsnano.0c03421.
Shipunova VO, Belova MM, Kotelnikova PA, Shilova ON, Mirkasymov AB, Danilova NV, Komedchikova EN, Popovtzer R, Deyev SM, Nikitin MP. Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission. Pharmaceutics (Q1). 2022; 14(5):1013. doi.org/10.3390/pharmaceutics14051013.
Obozina, A. S., Komedchikova, E. N., Kolesnikova, O. A., Iureva, A. M., Kovalenko, V. L., Zavalko, F. A., Rozhnikova, T.V., Tereshina, E. D., Mochalova E. N., Shipunova, V. O. (2023). Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics (Q1), 15(1), 231. DOI: 10.3390/pharmaceutics15010231.
Kovalenko, V. L., Komedchikova, E. N., Sogomonyan, A. S., Tereshina, E. D., Kolesnikova, O. A., Mirkasymov, A. B., Iureva, A. M., Zvyagin A.V., Nikitin P.I., Shipunova, V. O. (2023). Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics (Q1), 15(1), 92. DOI: 10.3390/pharmaceutics15010092.
Komedchikova, E. N., Kolesnikova, O. A., Tereshina, E. D., Kotelnikova, P. A., Sogomonyan, A. S., Stepanov, A. V., Deyev S.M., Nikitin M.P., Shipunova, V. O. (2023). Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics (Q1), 15(1), 52. DOI: 10.3390/pharmaceutics15010052.
Drozdov, A. S., Komarova, K. S., Mochalova, E. N., Komedchikova, E. N., Shipunova, V. O., & Nikitin, M. P. (2023). Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification. International Journal of Molecular Sciences (Q1), 24(1), 134. DOI: 10.3390/ijms24010134.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Shipunova VO, Belova MM, Kotelnikova PA, Shilova ON, Mirkasymov AB, Danilova NV, Komedchikova EN, Popovtzer R, Deyev SM, Nikitin MP. Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission. Pharmaceutics (Q1). 2022; 14(5):1013. doi.org/10.3390/pharmaceutics14051013.
Obozina, A. S., Komedchikova, E. N., Kolesnikova, O. A., Iureva, A. M., Kovalenko, V. L., Zavalko, F. A., Rozhnikova, T.V., Tereshina, E. D., Mochalova E. N., Shipunova, V. O. (2023). Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics (Q1), 15(1), 231. DOI: 10.3390/pharmaceutics15010231.
Kovalenko, V. L., Komedchikova, E. N., Sogomonyan, A. S., Tereshina, E. D., Kolesnikova, O. A., Mirkasymov, A. B., Iureva, A. M., Zvyagin A.V., Nikitin P.I., Shipunova, V. O. (2023). Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics (Q1), 15(1), 92. DOI: 10.3390/pharmaceutics15010092.
Komedchikova, E. N., Kolesnikova, O. A., Tereshina, E. D., Kotelnikova, P. A., Sogomonyan, A. S., Stepanov, A. V., Deyev S.M., Nikitin M.P., Shipunova, V. O. (2023). Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics (Q1), 15(1), 52. DOI: 10.3390/pharmaceutics15010052.
Drozdov, A. S., Komarova, K. S., Mochalova, E. N., Komedchikova, E. N., Shipunova, V. O., & Nikitin, M. P. (2023). Fluorescent Magnetic Nanoparticles for Bioimaging through Biomimetic Surface Modification. International Journal of Molecular Sciences (Q1), 24(1), 134. DOI: 10.3390/ijms24010134.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Основные публикации
Shipunova VO, Kolesnikova OA, Kotelnikova PA, Soloviev VD, Popov AA, Proshkina GM, Nikitin MP, Deyev SM. Comparative Evaluation of Engineered Polypeptide Scaffolds in HER2-Targeting Magnetic Nanocarrier Delivery. ACS Omega. 2021 Jun 10;6(24):16 000−16 008. doi: 10.1021/acsomega.1c01811. IF 4.1, Q1.
Kovalenko VL, Kolesnikova OA, Nikitin MP, Shipunova VO, Komedchikova EN. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Basel). 2023 Aug 21;14(8):1647. doi: 10.3390/mi14081647. IF 3.4, Q2.
Obozina AS, Komedchikova EN, Kolesnikova OA, Iureva AM, Kovalenko VL, Zavalko FA, Rozhnikova TV, Tereshina ED, Mochalova EN, Shipunova VO. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics. 2023 Jan 10;15(1):231. doi: 10.3390/pharmaceutics15010231. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Tereshina ED, Kotelnikova PA, Sogomonyan AS, Stepanov AV, Deyev SM, Nikitin MP, Shipunova VO. Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics. 2022 Dec 24;15(1):52. doi: 10.3390/pharmaceutics15010052. IF 5.4, Q1.
Kovalenko VL, Komedchikova EN, Sogomonyan AS, Tereshina ED, Kolesnikova OA, Mirkasymov AB, Iureva AM, Zvyagin AV, Nikitin PI, Shipunova VO. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics. 2022 Dec 27;15(1):92. doi: 10.3390/pharmaceutics15010092. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release. 2024 Jan;365:317−330. doi: 10.1016/j.jconrel.2023.11.036. Epub 2023 Nov 25. PMID: 37 996 056. IF 10.8, Q1.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Kovalenko VL, Kolesnikova OA, Nikitin MP, Shipunova VO, Komedchikova EN. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Basel). 2023 Aug 21;14(8):1647. doi: 10.3390/mi14081647. IF 3.4, Q2.
Obozina AS, Komedchikova EN, Kolesnikova OA, Iureva AM, Kovalenko VL, Zavalko FA, Rozhnikova TV, Tereshina ED, Mochalova EN, Shipunova VO. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics. 2023 Jan 10;15(1):231. doi: 10.3390/pharmaceutics15010231. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Tereshina ED, Kotelnikova PA, Sogomonyan AS, Stepanov AV, Deyev SM, Nikitin MP, Shipunova VO. Two-Step Targeted Drug Delivery via Proteinaceous Barnase-Barstar Interface and Doxorubicin-Loaded Nano-PLGA Outperforms One-Step Strategy for Targeted Delivery to HER2-Overexpressing Cells. Pharmaceutics. 2022 Dec 24;15(1):52. doi: 10.3390/pharmaceutics15010052. IF 5.4, Q1.
Kovalenko VL, Komedchikova EN, Sogomonyan AS, Tereshina ED, Kolesnikova OA, Mirkasymov AB, Iureva AM, Zvyagin AV, Nikitin PI, Shipunova VO. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics. 2022 Dec 27;15(1):92. doi: 10.3390/pharmaceutics15010092. IF 5.4, Q1.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release. 2024 Jan;365:317−330. doi: 10.1016/j.jconrel.2023.11.036. Epub 2023 Nov 25. PMID: 37 996 056. IF 10.8, Q1.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines (Q2) 2023, 14, 1647. doi.org/10.3390/mi14081647.
Shipunova, V.O.; Komedchikova, E.N.; Kotelnikova, P.A.; Nikitin, M.P.; Deyev, S.M. Targeted Two-Step Delivery of Oncotheranostic Nano-PLGA for HER2-Positive Tumor Imaging and Therapy In Vivo: Improved Effectiveness Compared to One-Step Strategy. Pharmaceutics (Q1) 2023, 15, 833. doi.org/10.3390/pharmaceutics15030833.
Komedchikova EN, Kolesnikova OA, Syuy AV, Volkov VS, Deyev SM, Nikitin MP, Shipunova VO. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. J Control Release (Q1). 2023 Nov 25; 365:317−330. doi: 10.1016/j.jconrel.2023.11.036.
Основные публикации
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. doi.org/10.3390/pharmaceutics15010231.
Основные публикации
Iureva et al. The influence of various polymer coatings on the in vitro and in vivo properties of PLGA nanoparticles: Comprehensive study // European Journal of Pharmaceutics and Biopharmaceutics. — 2024. — С. 114 366.
Kovalenko V. L. et al. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo //Pharmaceutics. — 2022. — Т. 15. — №. 1. — С. 92.
Obozina A. S. et al. Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo //Pharmaceutics. — 2023. — Т. 15. — №. 1. — С. 231.
Kotelnikova P. A. et al. Peroxidase-like activity of silver nanowires and its application for colorimetric detection of the antibiotic chloramphenicol //Talanta Open. — 2022. — Т. 6. — С. 100 164.
Kovalenko V. L. et al. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo //Pharmaceutics. — 2022. — Т. 15. — №. 1. — С. 92.
Obozina A. S. et al. Genetically encoded self-assembling protein nanoparticles for the targeted delivery in vitro and in vivo //Pharmaceutics. — 2023. — Т. 15. — №. 1. — С. 231.
Kotelnikova P. A. et al. Peroxidase-like activity of silver nanowires and its application for colorimetric detection of the antibiotic chloramphenicol //Talanta Open. — 2022. — Т. 6. — С. 100 164.
Основные публикации
Optical clearing of tissues: issues of antimicrobial phototherapy and drug delivery. VV Tuchin, EA Genina, ES Tuchina, AV Svetlakova, YI Svenskaya, Advanced Drug Delivery Reviews.
Исследование фотокаталитической антимикробной активности нанокомпозитов на основе TiO–AlO при воздействии светодиодного излучения. АВ Светлакова, ЕС Тучина, АН Ходан, ВВ Тучин, Оптика и спектроскопия.
Новые гипс-титановые композиты для антимикробного фотокаталитического воздействия на Staphylococcus aureus, Е Тучина, МВ Корченова, АВ Светлакова, К Криштиану, ВВ Тучин, Известия Саратовского университета. Новая серия.
Исследование фотокаталитической антимикробной активности нанокомпозитов на основе TiO–AlO при воздействии светодиодного излучения. АВ Светлакова, ЕС Тучина, АН Ходан, ВВ Тучин, Оптика и спектроскопия.
Новые гипс-титановые композиты для антимикробного фотокаталитического воздействия на Staphylococcus aureus, Е Тучина, МВ Корченова, АВ Светлакова, К Криштиану, ВВ Тучин, Известия Саратовского университета. Новая серия.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Основные публикации
Shipunova, V.O.; Kovalenko, V.L.; Kotelnikova, P.A.; Sogomonyan, A.S.; Shilova, O.N.; Komedchikova, E.N.; Zvyagin, A.V.; Nikitin, M.P.; Deyev, S.M. Targeting Cancer Cell Tight Junctions Enhances PLGA-Based Photothermal Sensitizers’ Performance In Vitro and In Vivo. Pharmaceutics 2022, 14, 43. https://doi.org/10.3390/pharmaceutics14010043.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
Obozina, A.S.; Komedchikova, E.N.; Kolesnikova, O.A.; Iureva, A.M.; Kovalenko, V.L.; Zavalko, F.A.; Rozhnikova, T.V.; Tereshina, E.D.; Mochalova, E.N.; Shipunova, V.O. Genetically Encoded Self-Assembling Protein Nanoparticles for the Targeted Delivery In Vitro and In Vivo. Pharmaceutics 2023, 15, 231. https://doi.org/10.3390/pharmaceutics15010231.
Kovalenko, V.L.; Komedchikova, E.N.; Sogomonyan, A.S.; Tereshina, E.D.; Kolesnikova, O.A.; Mirkasymov, A.B.; Iureva, A.M.; Zvyagin, A.V.; Nikitin, P.I.; Shipunova, V.O. Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo. Pharmaceutics 2023, 15, 92. https://doi.org/10.3390/pharmaceutics15010092.
Kovalenko, V.L.; Kolesnikova, O.A.; Nikitin, M.P.; Shipunova, V.O.; Komedchikova, E.N. Surface Characteristics Affect the Properties of PLGA Nanoparticles as Photothermal Agents. Micromachines 2023, 14, 1647. https://doi.org/10.3390/mi14081647.
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